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Citation:
Beggs, John M., James R.Moyer, Jr.,John P. McGann,and Thoms H. Brown. Prolonged synaptic integration of perihinal cortical neurons. J Neuro physiol 83: 3294-3298, 2000.
Abstract:
Layer II/III of rat perihinal cortex (PR) contains numerous late-spking (LS) pyramidial neurons. When injected with a depolarizing agent current step, these LS cells dypically delay spiking for one or more seconds from the onset of the current step and then sustain firing for the duration of the step. This pattern of delayed and sustained firing suggested a specific computation role for LS cells in temporal learning. This hypothesis predicts and requires that some layer II/III neurons should also exhibit delayed and sustained spiking in response to a train of excitatory synaptic inputs. Here we tested this prediction usuing visually guided, whole cell recordings from rat PR brain slices. Most LS cells (19 of 26) exhibited delayed spiking to synaptic stimulation (>1 s latency from the train onset) and the majority of these cells (13 of 19) also showed sustained firing that persisted for the duration of the synaptic train (5-10 s duration). Delayed and sustained firing in response to long synaptic trains has not been previously reported in vertebrate neurons. The data are consistent with our model that a circuit containing late spking neurons can be used for encoding long time intervals during associative learning.
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Added by: jbeggs 13 Dec 2003 3:42 PM
Last modified by: jbeggs 14 Dec 2003 10:48 PM
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Paper ID: 10
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